What Is VIP?

VIP — vasoactive intestinal peptide — is an endogenous 28-residue neuropeptide found through the gut, brain, lungs, and immune system. Few molecules in the catalogue carry a literature this broad: VIP has been a workhorse of receptor and signalling research since the 1970s.

What is VIP?

VIP is a native human peptide: twenty-eight residues acting through the VPAC1 and VPAC2 receptors, with roles described across smooth-muscle tone, immune modulation, circadian signalling, and secretory biology. Its breadth is the point — VIP sits near the centre of several fields at once.

What researchers study it for

As a well-mapped native sequence, VIP is a foundational reference peptide. Receptor-pharmacology work uses it as the benchmark agonist against which analogs are judged; immune and pulmonary models use it as the canonical VPAC-pathway input. The practical obstacle has always been supply: the native peptide degrades quickly and is impractical to isolate, so well-characterised synthetic VIP is what actually enables the work — reconstituted close to use, per the usual handling principles.

Working with research-grade VIP

REPRIME supplies VIP as a lyophilized 10 mg vial, HPLC-verified per batch with a public COA and first-scan verification code. See the VIP product page for the current batch. Research use only.

Frequently asked questions

What is VIP?

Vasoactive intestinal peptide — an endogenous 28-residue neuropeptide acting at the VPAC1/VPAC2 receptors, studied across immune, pulmonary, circadian, and smooth-muscle research.

Why is synthetic VIP used in research?

Because the native peptide degrades rapidly and cannot practically be isolated at research scale — synthesis provides the same sequence with verified identity and purity, batch after batch.

How is research-grade VIP supplied?

As a lyophilized 10 mg vial with a batch-specific COA and verification code — details on the product page.