Education
What Is Tesamorelin?
A GHRH analog with a single N-terminal modification that extends serum half-life from minutes to hours — what makes it useful in laboratory research.
Tesamorelin is a 44-amino-acid synthetic analog of growth-hormone-releasing hormone (GHRH). Researchers use it when they need a probe for the GHRH receptor with a kinetic profile longer than native GHRH provides. This article is the entry-level explainer; for the structural detail behind the N-terminal modification, see Tesamorelin in Endocrine Research.
A modified natural sequence
Native GHRH is a 44-residue peptide produced in the hypothalamus. Tesamorelin is essentially the same sequence with one structural modification: a trans-3-hexenoic acid group attached at the N-terminus. The modification doesn't change which receptor the peptide binds — it stays a GHRH-receptor agonist — but it dramatically changes how long the peptide survives before enzymatic degradation.
Why researchers prefer the modified form
Native GHRH is cleaved by dipeptidyl peptidase-4 (DPP-4) within minutes of entering serum. For most experimental protocols, that's too fast: by the time downstream signaling has been measured, the input signal has already decayed. Tesamorelin resists DPP-4 cleavage thanks to the hexenoic acid modification, extending serum half-life from minutes into a workable laboratory window.
Quality assurance
Identity is confirmed by mass spectrometry — the molecular weight verifies the hexenoic acid modification is present and the sequence is intact. Main-peak purity is quantified by HPLC against related substances and deletion peptides that can arise during synthesis. Both reports are published per batch in the Certificates repository.
What REPRIME's tesamorelin offers
- 20 mg lyophilized powder per vial
- Mass-spectrometry-confirmed identity (current batch)
- HPLC main-peak purity ≥99%
- Unique verification code on every package insert
- Public COA for every batch
Verification
Every package has a verification code. The first scan on /verify stamps it as verified; subsequent scans warn that the code has already been used — your anti-counterfeit signal — what a scan proves.
Positioning
Tesamorelin is research-grade material for endocrine and growth-hormone-axis studies only. REPRIME does not market it for any non-research application, does not provide dosage or protocol guidance, and does not make any medical claims.
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